Modeling the effect of dendritic input location on MEG and EEG source dipoles
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11517_2015_Article_1296.pdf
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Author(s)
Wreh, Christopher
Ahlfors, Seppo Pentti
Date Issued
April 2015
Journal
Medical & Biological Engineering & Computing
Publisher
Springer Berlin Heidelberg
Citation
Ahlfors, Seppo P., and Christopher Wreh. “Modeling the Effect of Dendritic Input Location on MEG and EEG Source Dipoles.” Medical & Biological Engineering & Computing 53, no. 9 (April 12, 2015): 879–887.
Version
Author's final manuscript
Abstract
The cerebral sources of magneto- and electroencephalography (MEG, EEG) signals can be represented by current dipoles. We used computational modeling of realistically shaped passive-membrane dendritic trees of pyramidal cells from the human cerebral cortex to examine how the spatial distribution of the synaptic inputs affects the current dipole. The magnitude of the total dipole moment vector was found to be proportional to the vertical location of the synaptic input. The dipole moment had opposite directions for inputs above and below a reversal point located near the soma. Inclusion of shunting-type inhibition either suppressed or enhanced the current dipole, depending on whether the excitatory and inhibitory synapses were on the same or opposite side of the reversal point. Relating the properties of the macroscopic current dipoles to dendritic current distributions can help to provide means for interpreting MEG and EEG data in terms of synaptic connection patterns within cortical areas.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s11517-015-1296-5
