The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection
Name
cancers-14-00909.pdf
Size
1.23 MB
Format
Adobe PDF
Checksum (MD5)
9db9ac68e6cd242012df92d6b2d85652
Author(s)
Harding, Alfred T.
Heaton, Nicholas S.
Date Issued
February 12, 2022
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Cancers 14 (4): 909 (2022)
Version
Final published version
Abstract
Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these “sex hormones” also regulate/influence a broad range of biological functions. In this review, we will summarize some current findings on how estrogens interact with and regulate inflammation and immunity. Specifically, we will focus on describing the mechanisms by which estrogens alter immune pathway activation, the impact of these changes during infection and the development of long-term immunity, and how different types of estrogens and their respective concentrations mediate these outcomes.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.3390/cancers14040909
