En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomography
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En face imaging.pdf
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Author(s)
Alasil, Tarek
Ferrara, Daniela
Adhi, Mehreen
Brewer, Erika
Baumal, Caroline R.
Hornegger, Joachim
Witkin, Andre J.
Reichel, Elias
Duker, Jay S.
Waheed, Nadia K.
Date Issued
December 2014
Journal
American Journal of Ophthalmology
Publisher
Elsevier
Citation
Alasil, Tarek; Ferrara, Daniela; Adhi, Mehreen et al. “En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomography.” American Journal of Ophthalmology 159, 4 (April 2015): 634–643 © 2015 Elsevier Inc
Version
Author's final manuscript
Abstract
Objective
To define morphologic features of polypoidal choroidal vasculopathy (PCV) using en face images from swept-source optical coherence tomography (SS OCT).
Design
Prospective cross-sectional study.
Methods
The study included 10 eyes from 6 patients with PCV and 10 eyes from 5 age-matched normal subjects. All subjects were prospectively scanned with a prototype SS OCT system. A motion correction algorithm was applied to correct and merge scans into a single volumetric dataset. En face images were generated at intervals of 4.13 μm (1 pixel) relative to the Bruch membrane.
Results
Age ± standard deviation for the normal group was 62.4 (±12.1) years and for the PCV group was 68.3 (±5.2) years. En face SS OCT imaging of PCV eyes demonstrated the relationship between larger pigment epithelial detachments (PEDs) and small adjoining PEDs that correlated with the polypoidal lesions seen on indocyanine green angiography in all PCV eyes. En face SS OCT demonstrated choroidal vascular abnormalities in 7 out of 7 eyes with PCV, and in 2 out of 3 enrolled fellow eyes in patients with unilateral PCV. Out of 7 PCV eyes, focal choroidal vascular dilation was noted in 3 eyes and diffuse choroidal vascular dilation was noted in 1 eye. In addition, a branching vascular network was noted above the Bruch membrane in 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal vascular layer in 1 eye.
Conclusions
En face SS OCT provides an in vivo tool to visualize the pathologic features and the choroidal vasculature in PCV.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1016/j.ajo.2014.12.012
