Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies
Name
New-2013-Use of Mixed Micelle.pdf
Size
324.82 KB
Format
Adobe PDF
Checksum (MD5)
f683969b4d6ead0cfe55377d1a2ba26a
Author(s)
New, Roger
Bansal, Gurpal
Bogus, Michael
Zajkowska, Kasia
Rickelt, Steffen
Toth, Istvan
Date Issued
March 2013
Journal
Molecules
Publisher
MDPI AG
Citation
New, Roger, Gurpal Bansal, Michael Bogus, Kasia Zajkowska, Steffen Rickelt, and Istvan Toth. “Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies.” Molecules 18, no. 3 (March 14, 2013): 3427–3441.
Version
Final published version
Abstract
We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/molecules18033427
