7.341 The DNA Damage Response as a Target for Anti-Cancer Therapy, Fall 2008
Author(s)
Reinhardt, Hans Christian
Alternative Title
The DNA Damage Response as a Target for Anti-Cancer Therapy
Date Issued
December 2008
Abstract
Cellular responses to DNA damage constitute one of the most important fields in cancer biology. In this class we will analyze classical and recent papers from the primary research literature to gain a profound understand of cell cycle regulation and DNA damage checkpoints that act as powerful emergency brakes to prevent cancer. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
DNA
damage checkpoints
cancer
cells
human cells
exogenous
endogenous
checkpoints
gene
signaling
cancer biology
cancer prevention
primary sources
discussion
DNA damage
molecular
enzyme
cell cycle
extracellular cues
growth factors
Cdk regulation
cyclin-dependent kinase
p53
tumor suppressor
apoptosis
signaling
MDC1
H2AX
Rad50
Fluorescence activated cell sorter
Chk1
mutant
MIT Department
Massachusetts Institute of Technology. Department of Biology
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