Deviation of innate circadian period from 24 hours reduces longevity in mice
Name
Guarente_Deviation of innate.pdf
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1.55 MB
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Checksum (MD5)
228215ee4177a3c37568104c7957a8c3
Author(s)
Bonkowski, Michael S.
Pointer, Kelli
Pletcher, Scott D.
Libert, Sergiy V.
Guarente, Leonard Pershing
Alternative Title
Deviation of innate circadian period from 24 h reduces longevity in mice
Date Issued
July 2012
Journal
Aging Cell
Publisher
Wiley Blackwell
Citation
Libert, Sergiy, Michael S. Bonkowski, Kelli Pointer, Scott D. Pletcher, and Leonard Guarente. “Deviation of innate circadian period from 24 h reduces longevity in mice.” Aging Cell 11, no. 5 (October 12, 2012): 794-800.
Version
Author's final manuscript
Abstract
The variation of individual life spans, even in highly inbred cohorts of animals and under strictly controlled environmental conditions, is substantial and not well understood. This variation in part could be due to epigenetic variation, which later affects the animal’s physiology and ultimately longevity. Identification of the physiological properties that impact health and life span is crucial for longevity research and the development of anti-aging therapies. Here, we measured individual circadian and metabolic characteristics in a cohort of inbred F1 hybrid mice and correlated these parameters to their life spans. We found that mice with innate circadian periods close to 24 h (revealed during 30 days of housing in total darkness) enjoyed nearly 20% longer life spans than their littermates, which had shorter or longer innate circadian periods. These findings show that maintenance of a 24-h intrinsic circadian period is a positive predictor of longevity. Our data suggest that circadian period may be used to predict individual longevity and that processes that control innate circadian period affect aging.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1111/j.1474-9726.2012.00846.x
