Radical-mediated ring contraction in the biosynthesis of 7-deazapurines
Name
Radical-mediated ring.pdf
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1.04 MB
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Adobe PDF
Checksum (MD5)
fc7104c6836db31e18f7085261c150d8
Author(s)
Bandarian, Vahe
Drennan, Catherine L.
Date Issued
November 2015
Journal
Current Opinion in Structural Biology
Publisher
Elsevier
Citation
Bandarian, Vahe, and Catherine L Drennan. “Radical-Mediated Ring Contraction in the Biosynthesis of 7-Deazapurines.” Current Opinion in Structural Biology 35 (2015): 116–124.
Version
Author's final manuscript
Abstract
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.sbi.2015.11.005
