Ultrasound-enhanced transdermal delivery: recent advances and future challenges
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Ultrasound-enhanced transdermal.pdf
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653.72 KB
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Author(s)
Blankschtein, Daniel
Oberli, Matthias
Langer, Robert S
Schoellhammer, Carl Magnus
Date Issued
July 2014
Journal
Therapeutic Delivery
Publisher
Future Science, LTD
Citation
Oberli, Matthias A, Carl M Schoellhammer, Robert Langer, and Daniel Blankschtein. “Ultrasound-Enhanced Transdermal Delivery: Recent Advances and Future Challenges.” Therapeutic Delivery 5, no. 7 (July 2014): 843–57.
Version
Author's final manuscript
Abstract
The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.4155/tde.14.32
