Response-dependent dynamics of cell-specific inhibition in cortical networks in vivo
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Sur_Response-dependent.pdf
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6.3 MB
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Checksum (MD5)
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Author(s)
El-Boustani, Sami
Sur, Mriganka
Date Issued
December 2014
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
El-Boustani, Sami, and Mriganka Sur. “Response-Dependent Dynamics of Cell-Specific Inhibition in Cortical Networks in Vivo.” Nature Communications 5 (December 11, 2014): 5689.
Version
Final published version
Abstract
In the visual cortex, inhibitory neurons alter the computations performed by target cells via combination of two fundamental operations, division and subtraction. The origins of these operations have been variously ascribed to differences in neuron classes, synapse location or receptor conductances. Here, by utilizing specific visual stimuli and single optogenetic probe pulses, we show that the function of parvalbumin-expressing and somatostatin-expressing neurons in mice in vivo is governed by the overlap of response timing between these neurons and their targets. In particular, somatostatin-expressing neurons respond at longer latencies to small visual stimuli compared with their target neurons and provide subtractive inhibition. With large visual stimuli, however, they respond at short latencies coincident with their target cells and switch to provide divisive inhibition. These results indicate that inhibition mediated by these neurons is a dynamic property of cortical circuits rather than an immutable property of neuronal classes.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/ncomms6689
