Understanding Metabolic Regulation and Its Influence on Cell Physiology
Name
Vander heiden_Understanding metabolic.pdf
Size
956.41 KB
Format
Adobe PDF
Checksum (MD5)
338542a119a704abfde7268ddef09258
Author(s)
Metallo, Christian M.
Vander Heiden, Matthew G.
Date Issued
February 2013
Journal
Molecular Cell
Publisher
Elsevier B.V.
Citation
Metallo, Christian M. and Matthew G. Vander Heiden (2013). "Understanding Metabolic Regulation and Its Influence on Cell Physiology." Molecular Cell 49(3): 388-398.
Version
Final published version
Abstract
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased expo- nentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.molcel.2013.01.018
