Current Developments and Challenges of mRNA Vaccines
Name
annurev-bioeng-110220-031722.pdf
Description
Published version
Size
1.01 MB
Format
Adobe PDF
Checksum (MD5)
6e3b6368c266b0e69e07dda851e9ad2b
Author(s)
Chen, Jinjin
Chen, Jianzhu
Xu, Qiaobing
Date Issued
2022
Journal
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Citation
Chen, Jinjin, Chen, Jianzhu and Xu, Qiaobing. 2022. "Current Developments and Challenges of mRNA Vaccines." Annual Review of Biomedical Engineering, 24 (1).
Version
Final published version
Abstract
mRNA vaccines have brought about a great revolution in the vaccine fields owing to their simplicity and adaptability in antigen design, potential to induce both humoral and cell-mediated immune responses and demonstrated high efficacy, and rapid and low-cost production by using the same manufacturing platform for different mRNA vaccines. Multiple mRNA vaccines have been investigated for both infectious diseases and cancers, showing significant superiority to other types of vaccines. Although great success of mRNA vaccines has been achieved in the control of the coronavirus disease 2019 pandemic, there are still multiple challenges for the future development of mRNA vaccines. In this review, the most recent developments of mRNA vaccines against both infectious diseases and cancers are summarized for an overview of this field. Moreover, the challenges are also discussed on the basis of these developments.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/ANNUREV-BIOENG-110220-031722
