Microfluidics Expanding the Frontiers of Microbial Ecology
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Stocker_Microfluidics expanding.pdf
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1.32 MB
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Author(s)
Rusconi, Roberto
Stocker, Roman
Garren, Melissa
Date Issued
May 2014
Journal
Annual Review of Biophysics
Publisher
Annual Reviews
Citation
Rusconi, Roberto, Melissa Garren, and Roman Stocker. “Microfluidics Expanding the Frontiers of Microbial Ecology.” Annu. Rev. Biophys. 43, no. 1 (May 6, 2014): 65–91.
Version
Author's final manuscript
Abstract
Microfluidics has significantly contributed to the expansion of the frontiers of microbial ecology over the past decade by allowing researchers to observe the behaviors of microbes in highly controlled microenvironments, across scales from a single cell to mixed communities. Spatially and temporally varying distributions of organisms and chemical cues that mimic natural microbial habitats can now be established by exploiting physics at the micrometer scale and by incorporating structures with specific geometries and materials. In this article, we review applications of microfluidics that have resulted in insightful discoveries on fundamental aspects of microbial life, ranging from growth and sensing to cell-cell interactions and population dynamics. We anticipate that this flexible multidisciplinary technology will continue to facilitate discoveries regarding the ecology of microorganisms and help uncover strategies to control microbial processes such as biofilm formation and antibiotic resistance.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Parsons Laboratory for Environmental Science and Engineering (Massachusetts Institute of Technology)
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1146/annurev-biophys-051013-022916
