Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
Name
1-s2.0-S2666379120302433-main.pdf
Description
Published version
Size
13.76 MB
Format
Adobe PDF
Checksum (MD5)
d1c75dc5426d45555dcf4fb7ab5d36bc
Author(s)
Sheppard, Hadley E
Dall’Agnese, Alessandra
Park, Woojun D
Shamim, M Hamza
Dubrulle, Julien
Johnson, Hannah L
Stossi, Fabio
Cogswell, Patricia
Sommer, Josh
Levy, Joan
Date Issued
2021
Journal
Cell Reports Medicine
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.xcrm.2020.100188
