Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
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Cheung-2014-Palladium-catalyzed.pdf
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Author(s)
Cheung, Chi Wai
Buchwald, Stephen Leffler
Date Issued
April 2014
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Cheung, Chi Wai, and Stephen L. Buchwald. “Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst.” The Journal of Organic Chemistry 79, no. 11 (June 6, 2014): 5351–5358. © 2014 American Chemical Society
Version
Final published version
Abstract
A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/jo500662s
