Constructing ensembles for intrinsically disordered proteins
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Stultz_Constructing ensembles.pdf
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Author(s)
Stultz, Collin M.
Fisher, Charles K.
Date Issued
April 2011
Journal
Current Opinion in Structural Biology
Publisher
Elsevier
Citation
Fisher, Charles K, and Collin M Stultz. “Constructing Ensembles for Intrinsically Disordered Proteins.” Current Opinion in Structural Biology 21, no. 3 (June 2011): 426–31.
Version
Author's final manuscript
Abstract
The relatively flat energy landscapes associated with intrinsically disordered proteins makes modeling these systems especially problematic. A comprehensive model for these proteins requires one to build an ensemble consisting of a finite collection of structures, and their corresponding relative stabilities, which adequately capture the range of accessible states of the protein. In this regard, methods that use computational techniques to interpret experimental data in terms of such ensembles are an essential part of the modeling process. In this review, we critically assess the advantages and limitations of current techniques and discuss new methods for the validation of these ensembles.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.sbi.2011.04.001
