Formation and Stability of Synaptic Receptor Domains
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Haselwandter-2011-Formation and Stabil.pdf
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Author(s)
Haselwandter, Christoph A.
Calamai, Martino
Kardar, Mehran
Triller, Antoine
Azeredo da Silveira, Rava
Date Issued
June 2011
Journal
Physical Review Letters
Publisher
American Physical Society
Citation
Haselwandter, Christoph et al. “Formation and Stability of Synaptic Receptor Domains.” Physical Review Letters 106 (2011). © 2011 American Physical Society.
Version
Final published version
Abstract
Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Combining experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model. We show that interactions between only receptors and scaffolds, together with the rapid diffusion of receptors on the cell membrane, are sufficient for the formation and stable characteristic size of synaptic receptor domains. Our work reconciles long-term stability of synaptic receptor domains with rapid turnover and diffusion of individual receptors, and suggests novel mechanisms for a form of short-term, postsynaptic plasticity.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.106.238104
