The effect of retroactivity on the transfer function of a phosphorylation system
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Del Vecchio_The effect.pdf
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328.09 KB
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Author(s)
Del Vecchio, Domitilla
Date Issued
October 2010
Journal
Proceedings of the 49th IEEE Conference on Decision and Control (CDC), 2010
Publisher
Institute of Electrical and Electronics Engineers
Citation
Del Vecchio, Domitilla. "The Effect of Retroactivity on the Transfer Function of a Phosphorylation System." In 49th IEEE Conference on Decision and Control, December 15-17, 2010, Hilton Atlanta Hotel, Atlanta, GA, USA, 2010, IEEE, Pp. 2523–2528. Web. © Copyright 2010 IEEE.
Version
Final published version
Abstract
It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1109/CDC.2010.5717674
