Task-dependent representations of stimulus and choice in mouse parietal cortex
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s41467-018-05012-y.pdf
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2.61 MB
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Author(s)
Sur, Mriganka
Pho, Gerald N
Goard, Michael
Woodson, Jonathan
Crawford, Benjamin C
Date Issued
July 2018
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Pho, Gerald N., Michael J. Goard, Jonathan Woodson, Benjamin Crawford, and Mriganka Sur. “Task-Dependent Representations of Stimulus and Choice in Mouse Parietal Cortex.” Nature Communications 9, no. 1 (July 3, 2018).
Version
Final published version
Abstract
The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in primary visual cortex (V1) and PPC during engaged behavior and passive viewing. Unlike V1 neurons, which respond robustly to stimuli in both conditions, most PPC neurons respond exclusively during task engagement. To test whether signals in PPC primarily encoded the stimulus or the animal's impending choice, we image the same neurons before and after re-training mice with a reversed sensorimotor contingency. Unlike V1 neurons, most PPC neurons reflect the animal's choice of the new target stimulus after re-training. Mouse PPC is therefore strongly task-dependent, reflects choice more than stimulus, and may play a role in the transformation of visual inputs into motor commands.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/s41467-018-05012-y
