Slow expanders invade by forming dented fronts in microbial colonies
Name
pnas.2108653119.pdf
Description
Published version
Size
1.29 MB
Format
Adobe PDF
Checksum (MD5)
ba97c07533500b5e22aede2def973915
Author(s)
Lee, Hyunseok
Gore, Jeff
Korolev, Kirill S
Date Issued
January 5, 2022
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Citation
Lee, Hyunseok, Gore, Jeff and Korolev, Kirill S. 2022. "Slow expanders invade by forming dented fronts in microbial colonies." Proceedings of the National Academy of Sciences, 119 (1).
Version
Final published version
Abstract
Significance
Living organisms never cease to evolve, so there is a significant interest in predicting and controlling evolution in all branches of life sciences. The most basic question is whether a trait should increase or decrease in a given environment. The answer seems to be trivial for traits such as the growth rate in a bioreactor or the expansion rate of a tumor. Yet, it has been suggested that such traits can decrease, rather than increase, during evolution. Here, we report a mutant that outcompeted the ancestor despite having a slower expansion velocity when in isolation. To explain this observation, we developed and validated a theory that describes spatial competition between organisms with different expansion rates and arbitrary competitive interactions.
MIT Department
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/pnas.2108653119
