Macro-to-Micro Interface for the Control of Cellular Organization
Name
Bhatia_Marcro-to-micro.pdf
Size
648.59 KB
Format
Adobe PDF
Checksum (MD5)
804f79a195882ec24a07aaa8d8d9a2c9
Author(s)
Hui, Elliot E.
Li, Chun
Agrawal, Amit
Bhatia, Sangeeta N.
Date Issued
March 2014
Journal
Journal of Microelectromechanical Systems
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Hui, Elliot E., Chun Li, Amit Agrawal, and Sangeeta N. Bhatia. “Macro-to-Micro Interface for the Control of Cellular Organization.” J. Microelectromech. Syst. 23, no. 2 (April 2014): 391–397.
Version
Author's final manuscript
Abstract
The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/jmems.2013.2278813
