Monolithic Silica Support for Immobilized Catalysis in Continuous Flow
Author(s)
Russell, Mary Grace.
Veryser, Cedrick
Hunter, James Freeman
Beingessner, Rachel L
Jamison, Timothy F.
Date Issued
December 2019
Journal
Advanced Synthesis and Catalysis
Publisher
Wiley
Citation
Russell, M. Grace et al. "Monolithic Silica Support for Immobilized Catalysis in Continuous Flow." Advanced Synthesis and Catalysis 362, 2 (January 2020): 314-319 © 2019 Wiley
Version
Author's final manuscript
Abstract
Monolithic and packed‐bed reactors featuring immobilized catalysts are well‐precedented in continuous flow synthesis but can suffer from adverse pressure drops during use due to their small pore sizes and/or structural changes. Herein, we overcome this challenge with the synthesis of a structurally robust silica‐based monolith featuring pore sizes on the millimeter scale. The 3‐dimensional solid support structure is constructed from a polystyrene foam‐based template and features a functional group handle that can be modified to display a reactive catalyst. Here we functionalize the support with palladium(0) for hydrogenation reactions and a modified proline catalyst for the alpha functionalization of aldehydes. Both reactors showed good activity and excellent catalytic longevity when utilized under continuous flow conditions.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adsc.201901185
