Molecular Tools and Approaches for Optogenetics
Name
Zhang_Molecular tools.pdf
Size
364.49 KB
Format
Adobe PDF
Checksum (MD5)
f8e857d63a228647fc6bd025d8c5f3b2
Author(s)
Mei, Yuan
Zhang, Feng
Date Issued
February 2012
Journal
Biological Psychiatry
Publisher
Elsevier
Citation
Mei, Yuan, and Feng Zhang. “Molecular Tools and Approaches for Optogenetics.” Biological Psychiatry 71, no. 12 (June 2012): 1033–1038.
Version
Author's final manuscript
Abstract
The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis. Technologies that facilitate functional dissection of distinct brain circuits are necessary for systematic identification of disease origin and therapy. Recent developments in optogenetics technology have begun to address this challenge by enabling precise perturbation of distinct cell types based on molecular signatures, functional projections, and intracellular biochemical signaling pathways. With high temporal precision and reversible neuromodulation, optogenetics promises to improve existing disease models and advance our understanding of psychiatric conditions. In this review, we describe the current state of molecular optogenetic tools and future directions of development.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.biopsych.2012.02.019
