Collective antibiotic resistance: mechanisms and implications
Name
Collective antibiotic resistance.pdf
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724.42 KB
Format
Adobe PDF
Checksum (MD5)
90c57838a9ee6140c37ea7ec3e11c638
Author(s)
Vega, Nicole
Gore, Jeff
Date Issued
September 2014
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Citation
Vega, Nicole M and Gore, Jeff. “Collective Antibiotic Resistance: Mechanisms and Implications.” Current Opinion in Microbiology 21 (October 2014): 28–34. © 2014 Elsevier Ltd
Version
Author's final manuscript
Abstract
In collective resistance, microbial communities are able to survive antibiotic exposures that would be lethal to individual cells. In this review, we explore recent advances in understanding collective resistance in bacteria. The population dynamics of ‘cheating’ in a system with cooperative antibiotic inactivation have been described, providing insight into the demographic factors that determine resistance allele frequency in bacteria. Extensive work has elucidated mechanisms underlying collective resistance in biofilms and addressed questions about the role of cooperation in these structures. Additionally, recent investigations of ‘bet-hedging’ strategies in bacteria have explored the contributions of stochasticity and regulation to bacterial phenotypic heterogeneity and examined the effects of these strategies on community survival.
MIT Department
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.mib.2014.09.003
