Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions
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s41467-022-29384-4.pdf
Description
Published version
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3.19 MB
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Checksum (MD5)
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Author(s)
Roy, Dheeraj S
Park, Young-Gyun
Kim, Minyoung E
Zhang, Ying
Ogawa, Sachie K
DiNapoli, Nicholas
Gu, Xinyi
Cho, Jae H
Choi, Heejin
Kamentsky, Lee
Date Issued
2022
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Roy, Dheeraj S, Park, Young-Gyun, Kim, Minyoung E, Zhang, Ying, Ogawa, Sachie K et al. 2022. "Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions." Nature Communications, 13 (1).
Version
Final published version
Abstract
AbstractNeuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex. Here, we report a partial map of the engram complex for contextual fear conditioning memory by characterizing encoding activated neuronal ensembles in 247 regions using tissue phenotyping in mice. The mapping was aided by an engram index, which identified 117 cFos+ brain regions holding engrams with high probability, and brain-wide reactivation of these neuronal ensembles by recall. Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams. Simultaneous chemogenetic reactivation of multiple engram ensembles conferred a greater level of memory recall than reactivation of a single engram ensemble, reflecting the natural memory recall process. Overall, our study supports the unified engram complex hypothesis for memory storage.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/S41467-022-29384-4
