Investigating EEG burst suppression for coma outcome prediction
Name
1080642416-MIT.pdf
Description
Full printable version
Size
4.13 MB
Format
Adobe PDF
Checksum (MD5)
c701993125d2174329a71ab61032b12e
Author(s)
Zhan, Tiange
Advisor(s)
Una-May O'Reilly and Abdullah Al-Dujaili.
Alternative Title
Investigating electroencephalogram burst suppression for coma outcome prediction
Date Issued
2018
Publisher
Massachusetts Institute of Technology
Abstract
Every year, over 300,000 incidents of cardiac arrest occur in the United States. Of the people who are successfully resuscitated and brought to the hospital, approximately 80% remain unconscious for some amount of time Marion [2009]. Predicting whether or not a patient will wake up from coma, as well as the patient's neurological function after waking up, is an important task in guiding treatment decisions for physicians and family of the patient. This project seeks to improve this prediction process by analyzing features of the patients' EEG recordings during coma with the aim to determine quantitative metrics which are predictive of patients' outcome. Specifically, we focus on the analysis of the similarity of bursts during burst suppression, which has been hypothesized to be linked with poor outcome. Our work confirms that similarity of bursts is indeed linked with poor outcome, and we also find that dynamic time warping gives a viable alternative to the previously used method of cross-correlation as a measure of similarity of bursts, with good predictive power for patient outcome.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
"June 2018." Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 97-100).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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