Cortical recording with conducting polymer electrodes
Name
302268472-MIT.pdf
Description
Full printable version
Size
18.49 MB
Format
Adobe PDF
Checksum (MD5)
5be671b0c63e1140231fec0ce988ac9e
Author(s)
Bae, Woong Jin
Advisor(s)
Emilio Bizzi and Ian W. Hunter.
Date Issued
2008
Publisher
Massachusetts Institute of Technology
Abstract
The ability to record from the same neuron for extended periods of time is essential to understanding how the brain reorganizes during motor learning. Conventional chronic recording microelectrodes are made from metal or silicon. However, the large stiffness mismatch between the electrodes and brain tissue causes shear-induced inflammation, limiting long-term recording stability. The flexibility of a polypyrrole microwire has the potential to improve the chronic recording stability by minimizing the stiffness mismatch. This thesis shows the fabrication of conducting polymer electrodes and the stability of their impedance in physiological saline. The initial impedance was as low as 70 k[omega], but the electrode impedance increased by a factor of 10 when immersed in saline over 370 hours. This conducting polymer microwire electrode was implanted in a rodent brain and successfully used to record neuronal action potentials.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.
Includes bibliographical references (leaves 39-41).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
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