Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome during Learning
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Author(s)
Atallah, Hisham E.
McCool, Andrew D.
Howe, Mark W.
Graybiel, Ann M.
Atallah, Hisham E.
McCool, Andrew D.
Howe, Mark W.
Graybiel, Ann M.
Date Issued
June 2014
Journal
Neuron
Publisher
Elsevier
Citation
Atallah, Hisham E., Andrew D. McCool, Mark W. Howe, and Ann M. Graybiel. “Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome During Learning.” Neuron 82, no. 5 (June 2014): 1145–1156.
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Author's final manuscript
Abstract
The ventromedial striatum (VMS) is a node in circuits underpinning both affect and reinforcement learning. The cellular bases of these functions and especially their potential linkages have been unclear. VMS cholinergic interneurons, however, have been singled out as being related both to affect and to reinforcement-based conditioning, raising the possibility that unique aspects of their signaling could account for these functions. Here we show that VMS tonically active neurons (TANs), including putative cholinergic interneurons, generate unique bidirectional outcome responses during reward-based learning, reporting both positive (reward) and negative (reward omission) outcomes when behavioral change is prompted by switches in reinforcement contingencies. VMS output neurons (SPNs), by contrast, are nearly insensitive to switches in reinforcement contingencies, gradually losing outcome signaling while maintaining responses at trial initiation and goal approach. Thus, TANs and SPNs in the VMS provide distinct signals optimized for different aspects of the learning process.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2014.04.021
