Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness
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Ching-2010-Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness.pdf
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1.58 MB
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Checksum (MD5)
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Author(s)
Ching, Shinung
Cimenser, Aylin
Purdon, Patrick Lee
Brown, Emery N.
Kopell, Nancy J.
Date Issued
December 2010
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences
Citation
Ching, S. et al. “Thalamocortical Model for a Propofol-induced -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670.
Version
Final published version
Abstract
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1017069108
