Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction
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Stoeck-2014-Dual-phase cardiac d.pdf
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Author(s)
Stoeck, Christian T.
Kalinowska, Aleksandra
von Deuster, Constantin
Harmer, Jack
Chan, Rachel W.
Niemann, Markus
Manka, Robert
Atkinson, David
Sosnovik, David E.
Mekkaoui, Choukri
Date Issued
September 2014
Journal
PLoS ONE
Publisher
Public Library of Science
Citation
Stoeck, Christian T., Aleksandra Kalinowska, Constantin von Deuster, Jack Harmer, Rachel W. Chan, Markus Niemann, Robert Manka, et al. “Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction.” Edited by Alexander Leemans. PLoS ONE 9, no. 9 (September 5, 2014): e107159.
Version
Final published version
Abstract
Purpose:
In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging.
Methods:
In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10 healthy volunteers. The time course of material strain was estimated from the tagging data and used to correct for strain effects in the diffusion weighted acquisition. Mean diffusivity, fractional anisotropy, helix, transverse and sheet angles were calculated and compared between systole and diastole, with and without strain correction. Data acquired at the systolic sweet spot, where the effects of strain are eliminated, served as a reference.
Results:
The impact of strain correction on helix angle was small. However, large differences were observed in the transverse and sheet angle values, with and without strain correction. The standard deviation of systolic transverse angles was significantly reduced from 35.9±3.9° to 27.8°±3.5° (p<0.001) upon strain-correction indicating more coherent fiber tracks after correction. Myocyte aggregate structure was aligned more longitudinally in systole compared to diastole as reflected by an increased transmural range of helix angles (71.8°±3.9° systole vs. 55.6°±5.6°, p<0.001 diastole). While diastolic sheet angle histograms had dominant counts at high sheet angle values, systolic histograms showed lower sheet angle values indicating a reorientation of myocyte sheets during contraction.
Conclusion:
An approach for dual-phase cardiac DTI with correction for material strain has been successfully implemented. This technique allows assessing dynamic changes in myofiber architecture between systole and diastole, and emphasizes the need for strain correction when sheet architecture in the heart is imaged with a stimulated echo approach.
MIT Department
Massachusetts Institute of Technology. Center for Biomedical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
https://doi.org/10.1371/journal.pone.0107159
