Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo
Name
nihms834520.pdf
Description
Accepted version
Size
219.29 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Luo, X.
Wang, Wei
Dorkin, Joseph Robert
Veiseh, Omid
Chang, Pyung-Hun
Abutbul-Ionita, I.
Danino, D.
Langer, Robert S
Anderson, Daniel Griffith
Dong, Y.
Date Issued
January 2017
Journal
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Citation
Luo, X. et al. "Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo." Biomaterials Science 1 (January 2017): 38-40 © 2017 The Royal Society of Chemistry
Version
Author's final manuscript
Abstract
Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c6bm00683c
