Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods
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Strano_Reactive oxygen.pdf
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Author(s)
Patra, Chitta Ranjan
Kim, Jong-Ho
Pramanik, Kallal
d’Uscio, Livius V.
Patra, Sujata
Pal, Krishnendu
Ramchandran, Ramani
Strano, Michael S.
Mukhopadhyay, Debabrata
Date Issued
November 2011
Journal
Nano Letters
Publisher
American Chemical Society
Citation
Patra, Chitta Ranjan, Jong-Ho Kim, Kallal Pramanik, Livius V. d’Uscio, Sujata Patra, Krishnendu Pal, Ramani Ramchandran, Michael S. Strano, and Debabrata Mukhopadhyay. Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods. Nano Letters 11, no. 11 (November 9, 2011): 4932-4938.
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Author's final manuscript
Abstract
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·−) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·– from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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DOI of Published Version
https://doi.org/10.1021/nl2028766
