Toxoplasma gondii effectors are master regulators of the inflammatory response
Name
TREPAR_Manuscript.pdf
Size
1.49 MB
Format
Adobe PDF
Checksum (MD5)
e4c5d0375a758630498d39fc8973c602
Author(s)
Melo, Mariane Bandeira
Saeij, Jeroen
Jensen, Kirk D.
Date Issued
September 2011
Journal
Trends in Parasitology
Publisher
Elsevier
Citation
Melo, Mariane B., Kirk D.C. Jensen, and Jeroen P.J. Saeij. “Toxoplasma Gondii Effectors Are Master Regulators of the Inflammatory Response.” Trends in Parasitology 27, no. 11 (November 2011): 487–495.
Version
Author's final manuscript
Abstract
Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To do this, it must carefully regulate immune activation and host cell effector mechanisms. Here we review the latest developments in our understanding of how Toxoplasma counteracts the immune response of the host, and in some cases provokes it, through the use of specific parasite effector proteins. An emerging theme from these discoveries is that Toxoplasma effectors are master regulators of the pro-inflammatory response, which elicits many of the toxoplasmacidal mechanisms of the host. We speculate that combinations of these effectors present in certain Toxoplasma strains work to maintain an optimal parasite burden in different hosts to ensure parasite transmission.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.pt.2011.08.001
