Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
Name
nihms-1664280.pdf
Description
Accepted version
Size
1.17 MB
Format
Adobe PDF
Checksum (MD5)
3ead41002e56534b55fc85c589cbb520
Author(s)
Tan, Xiao
Letendre, Justin H
Collins, James J
Wong, Wilson W
Date Issued
2021
Journal
Cell
Publisher
Elsevier BV
Citation
Tan, Xiao, Letendre, Justin H, Collins, James J and Wong, Wilson W. 2021. "Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics." Cell, 184 (4).
Version
Author's final manuscript
Abstract
© 2021 Elsevier Inc. Synthetic biology is a design-driven discipline centered on engineering novel biological functions through the discovery, characterization, and repurposing of molecular parts. Several synthetic biological solutions to critical biomedical problems are on the verge of widespread adoption and demonstrate the burgeoning maturation of the field. Here, we highlight applications of synthetic biology in vaccine development, molecular diagnostics, and cell-based therapeutics, emphasizing technologies approved for clinical use or in active clinical trials. We conclude by drawing attention to recent innovations in synthetic biology that are likely to have a significant impact on future applications in biomedicine.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Synthetic Biology Center
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2021.01.017
