Dual Responsiveness of a Tunable Thermosensitive Polypeptide
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Griffith_Dual respnsiveness.pdf
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Author(s)
Chopko Ahrens, Caroline
Lowden, Erika L.
Engler, Amanda C.
Griffith, Linda G.
Hammond, Paula T.
Date Issued
June 2012
Journal
ACS Macro Letters
Publisher
American Chemical Society (ACS)
Citation
Chopko, Caroline M., Erika L. Lowden, Amanda C. Engler, Linda G. Griffith, and Paula T. Hammond. “Dual Responsiveness of a Tunable Thermosensitive Polypeptide.” ACS Macro Lett. 1, no. 6 (June 19, 2012): 727–731. © 2012 American Chemical Society.
Version
Final published version
Abstract
The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo(ethylene glycol) and diisopropylamine side groups.
MIT Department
Massachusetts Institute of Technology. Center for Gynepathology Research
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/mz300088w
