Analogous Convergence of Sustained and Transient Inputs in Parallel On and Off Pathways for Retinal Motion Computation
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Greene-2016-Analogous Convergenc.pdf
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3.51 MB
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Author(s)
Greene, Matthew J.
Kim, Jinseop S.
Seung, H. Sebastian
Greene, Matthew J.
Date Issued
February 2016
Journal
Cell Reports
Publisher
Elsevier
Citation
Greene, Matthew J., Jinseop S. Kim, and H. Sebastian Seung. “Analogous Convergence of Sustained and Transient Inputs in Parallel On and Off Pathways for Retinal Motion Computation.” Cell Reports 14, no. 8 (March 2016): 1892–1900.
Version
Final published version
Abstract
Visual motion information is computed by parallel On and Off pathways in the retina, which lead to On and Off types of starburst amacrine cells (SACs). The approximate mirror symmetry between this pair of cell types suggests that On and Off pathways might compute motion using analogous mechanisms. To test this idea, we reconstructed On SACs and On bipolar cells (BCs) from serial electron microscopic images of a mouse retina. We defined a new On BC type in the course of classifying On BCs. Through quantitative contact analysis, we found evidence that sustained and transient On BC types are wired to On SAC dendrites at different distances from the SAC soma, mirroring our previous wiring diagram for the Off BC-SAC circuit. Our finding is consistent with the hypothesis that On and Off pathways contain parallel correlation-type motion detectors.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1016/j.celrep.2016.02.001
