A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
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s41540-025-00501-5.pdf
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Author(s)
Ayyadurai, V. A. Shiva
Deonikar, Prabhakar
Kamm, Roger D.
Date Issued
March 17, 2025
Journal
npj Systems Biology and Applications
Publisher
Nature Publishing Group UK
Citation
Ayyadurai, V.A.S., Deonikar, P. & Kamm, R.D. A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis. npj Syst Biol Appl 11, 27 (2025).
Version
Final published version
Abstract
A molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process. ALS is a fatal motor neuron disease characterized by progressive degeneration of the upper and lower motor neurons that supply voluntary muscles. The neuromuscular junction contains cells such as upper and lower motor neurons, skeletal muscle cells, astrocytes, microglia, Schwann cells, and endothelial cells, which are implicated in pathogenesis of ALS. This molecular systems architecture provides a multi-layered understanding of the intra- and inter-cellular interactions in the ALS neuromuscular junction microenvironment, and may be utilized for target identification, discovery of single and combination therapeutics, and clinical strategies to treat ALS.
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DOI of Published Version
https://doi.org/10.1038/s41540-025-00501-5
