Calorie restriction and sirtuins revisited
Name
Guarente_Calorie restriction.pdf
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732.89 KB
Format
Adobe PDF
Checksum (MD5)
7ca0a1f724efd6368a6efd8c7677704f
Author(s)
Guarente, Leonard Pershing
Date Issued
October 2013
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory Press
Citation
Guarente, L. “Calorie restriction and sirtuins revisited.” Genes & Development 27, no. 19 (October 10, 2013): 2072-2085.
Version
Author's final manuscript
Abstract
Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Terms of Use
Creative Commons Attribution-Noncommercial 3.0
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DOI of Published Version
https://doi.org/10.1101/gad.227439.113
