Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo
Name
pnas.2117764119.pdf
Description
Published version
Size
2.2 MB
Format
Adobe PDF
Checksum (MD5)
71f30aa3b25aa9c2909168439e29c0e5
Author(s)
Flavin, Matthew T
Paul, Marek A
Lim, Alexander S
Lissandrello, Charles A
Ajemian, Robert J.
Lin, Samuel J
Han, Jongyoon
Date Issued
June 7, 2022
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Citation
Flavin, Matthew T, Paul, Marek A, Lim, Alexander S, Lissandrello, Charles A, Ajemian, Robert et al. 2022. "Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo." Proceedings of the National Academy of Sciences, 119 (23).
Version
Final published version
Abstract
Significance
Bioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigated ion-concentration modulation with ion-selective membranes and whether this modality may enhance the functional selectivity of peripheral nerve stimulation. We designed a multimodal stimulator that could control Ca 2+ concentrations within a focused volume. Acutely implanting it on the sciatic nerve of a rat, we demonstrated that Ca 2+ depletion could increase the sensitivity of the nerve to electrical stimulation in vivo. We provided evidence that it selectively influenced individual fascicles of the nerve, allowing selective activation by electrical current. Improved functional selectivity may improve outcomes for important therapeutic modalities.
Bioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigated ion-concentration modulation with ion-selective membranes and whether this modality may enhance the functional selectivity of peripheral nerve stimulation. We designed a multimodal stimulator that could control Ca 2+ concentrations within a focused volume. Acutely implanting it on the sciatic nerve of a rat, we demonstrated that Ca 2+ depletion could increase the sensitivity of the nerve to electrical stimulation in vivo. We provided evidence that it selectively influenced individual fascicles of the nerve, allowing selective activation by electrical current. Improved functional selectivity may improve outcomes for important therapeutic modalities.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
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DOI of Published Version
https://doi.org/10.1073/pnas.2117764119
