Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo
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nihms496482.pdf
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Author(s)
Fukumura, Dai
Jain, Rakesh K.
Han, Hee-Sun
Martin, John Daniel
Lee, Jungmin
Harris, Daniel Kelly
Bawendi, Moungi G
Date Issued
January 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Han, Hee-Sun et al. “Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo.” Angewandte Chemie International Edition 52, 5 (December 2012): 1414–1419 © 2013 WILEY-VCH Verlag GmbH & Co
Version
Author's final manuscript
Abstract
Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201208331
