Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions
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Imperiali_Caged mono paper and SI.pdf
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Author(s)
Sainlos, Matthieu
Iskenderian, Wendy S.
Olivier, Nelson B.
Choquet, Daniel
Imperiali, Barbara
Date Issued
March 2013
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Citation
Sainlos, Mathieu, Wendy S. Iskenderian-Epps, Nelson B. Olivier, Daniel Choquet, and Barbara Imperiali. "Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions." Journal of the American Chemical Society, 2013, 135 (12), pp 4580–4583.
Version
Author's final manuscript
Abstract
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ja309870q
