Synthesis of Spirocyclic Indolines by Interruption of the Bischler–Napieralski Reaction
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Movassaghi_Synthesis of spirocyclic.pdf
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Author(s)
Medley, Jonathan William
Movassaghi, Mohammad
Date Issued
July 2013
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Medley, Jonathan William, and Mohammad Movassaghi. “Synthesis of Spirocyclic Indolines by Interruption of the Bischler–Napieralski Reaction.” Org. Lett. 15, no. 14 (July 19, 2013): 3614–3617.
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Author's final manuscript
Abstract
The development of a versatile method for the synthesis of spirocyclic pyrrolidinoindolines is discussed. Treatment of N-acyltryptamines with trifluoromethanesulfonic anhydride–2-chloropyridine reagent combination affords highly persistent spiroindoleninium ions that are subject to intra- and intermolecular addition at C2 by nucleophiles.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ol401465y
