Configurational fingerprints of multicellular living systems
Name
e2109168118.full.pdf
Description
Published version
Size
2.33 MB
Format
Unknown
Checksum (MD5)
388d54fc655a7dbcc7ed4b3f0419ef48
Author(s)
Yang, Haiqian
Pegoraro, Adrian F
Han, Yulong
Tang, Wenhui
Abeyaratne, Rohan
Bi, Dapeng
Guo, Ming
Date Issued
November 2021
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Citation
Yang, Haiqian, Pegoraro, Adrian F, Han, Yulong, Tang, Wenhui, Abeyaratne, Rohan et al. 2021. "Configurational fingerprints of multicellular living systems." Proceedings of the National Academy of Sciences, 118 (44).
Version
Final published version
Abstract
Cells cooperate as groups to achieve structure and function at the tissue level, during which specific material characteristics emerge. Analogous to phase transitions in classical physics, transformations in the material characteristics of multicellular assemblies are essential for a variety of vital processes including morphogenesis, wound healing, and cancer. In this work, we develop configurational fingerprints of particulate and multicellular assemblies and extract volumetric and shear order parameters based on this fingerprint to quantify the system disorder. Theoretically, these two parameters form a complete and unique pair of signatures for the structural disorder of a multicellular system. The evolution of these two order parameters offers a robust and experimentally accessible way to map the phase transitions in expanding cell monolayers and during embryogenesis and invasion of epithelial spheroids.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/pnas.2109168118
