The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design
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Karsten-2017-The HIV-1 Glycan Shield_ Strategi.pdf
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376.98 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Karsten, Christina Beatrice
Alter, Galit
Date Issued
April 2017
Journal
Cell Reports
Publisher
Elsevier
Citation
Karsten, Christina Beatrice and Alter, Galit. “The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design.” Cell Reports 19, no. 4 (April 2017): 669–670 © 2017 Elsevier B.V.
Version
Final published version
Abstract
Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.
MIT Department
Ragon Institute of MGH, MIT and Harvard
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.celrep.2017.04.033
