Starting a new chapter on class Ia ribonucleotide reductases
Name
1-s2.0-S0959440X22001683-main.pdf
Description
Published version
Size
3.15 MB
Format
Adobe PDF
Checksum (MD5)
721349d522c1064272b5f91cce4a684b
Author(s)
Levitz, Talya S
Drennan, Catherine L
Date Issued
December 2022
Journal
Current Opinion in Structural Biology
Publisher
Elsevier BV
Citation
Levitz, Talya S and Drennan, Catherine L. 2022. "Starting a new chapter on class Ia ribonucleotide reductases." Current Opinion in Structural Biology, 77.
Version
Final published version
Abstract
Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of class Ia RNRs, including a recent reporting of a structure of the active state of the E. coli enzyme and the impacts that the structure has had on spurring research into the mechanism of long-range radical transfer. Additionally, the review considers other recent structural and biochemical research on class Ia RNRs and the potential of that work for the development of anticancer and antibiotic therapeutics.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.sbi.2022.102489
