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Flexible Sensorimotor Computations through Rapid Reconfiguration of Cortical Dynamics
Name
nihms972922.pdf
Description
Accepted version
Size
1.51 MB
Format
Adobe PDF
Checksum (MD5)
144101adaec09109f134e1e92ec74be2
Author(s)
Remington, Evan D
Narain, Devika
Hosseini, Eghbal A
Jazayeri, Mehrdad
Date Issued
2018
Journal
Neuron
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2018 Elsevier Inc. Neural mechanisms that support flexible sensorimotor computations are not well understood. In a dynamical system whose state is determined by interactions among neurons, computations can be rapidly reconfigured by controlling the system's inputs and initial conditions. To investigate whether the brain employs such control mechanisms, we recorded from the dorsomedial frontal cortex of monkeys trained to measure and produce time intervals in two sensorimotor contexts. The geometry of neural trajectories during the production epoch was consistent with a mechanism wherein the measured interval and sensorimotor context exerted control over cortical dynamics by adjusting the system's initial condition and input, respectively. These adjustments, in turn, set the speed at which activity evolved in the production epoch, allowing the animal to flexibly produce different time intervals. These results provide evidence that the language of dynamical systems can be used to parsimoniously link brain activity to sensorimotor computations. Remington et al. employ a dynamical systems perspective to understand how the brain flexibly controls timed movements. Results suggest that neurons in the frontal cortex form a recurrent network whose behavior is flexibly controlled by inputs and initial conditions.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.NEURON.2018.05.020
