Intramolecular [4 + 2] cycloadditions of conjugated enynes with highly strained cyclic alkenes
Name
262478899-MIT.pdf
Description
Full printable version
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3.02 MB
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Checksum (MD5)
e93185f1f1a894bce692c5c5f10de927
Author(s)
Fong, Jennie
Advisor(s)
Rick L. Danheiser.
Date Issued
2008
Publisher
Massachusetts Institute of Technology
Abstract
Seven- and eight-membered carbocycles are key features in numerous naturally occurring organic substances, many of which are biologically important natural products. This thesis describes studies directed towards the development of a [4 + 3] annulation strategy for the synthesis of seven-membered carbocycles involving the intramolecular [4 + 2] cycloadditions of conjugated enynes with cyclopropenes. A new [4 + 4] annulation method has been developed for the synthesis of eight-membered carbocycles involving cycloadditions of cyclobutenones with conjugated enynes.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.
Vita.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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