Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography
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Kagemann-2007-Spectral oximetry as.pdf
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Author(s)
Kagemann, Larry
Wollstein, Gadi
Wojtkowski, Maciej
Ishikawa, Hiroshi
Townsend, Kelly A.
Gabriele, Michelle L.
Srinivasan, Vivek J.
Fujimoto, James G.
Schuman, Joel S.
Date Issued
August 2007
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Kagemann, Larry, Gadi Wollstein, Maciej Wojtkowski, Hiroshi Ishikawa, Kelly A. Townsend, Michelle L. Gabriele, Vivek J. Srinivasan, James G. Fujimoto, and Joel S. Schuman. “Spectral Oximetry Assessed with High-Speed Ultra-High-Resolution Optical Coherence Tomography.” Journal of Biomedical Optics 12, no. 4 (2007): 041212. © 2007 Society of Photo-Optical Instrumentation Engineers
Version
Final published version
Abstract
We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subjects. After removing DC and low-frequency a-scan components, an OCT fundus image was created by integrating total reflectance into a single reflectance value. Thirty fringe patterns were sampled; 10 each from the edge of an artery, adjacent tissue, and the edge of a vein, respectively. A-scans were recalculated, zeroing the DC term in the power spectrum, and used for analysis. Optical density ratios (ODRs) were calculated as ODR[subscript Art] = ln(Tissue[subscript 855]/Art[subscript 855])/ln(Tissue[subscript 805]/Art[subscript 805) and ODR[subscript Vein] = ln(Tissue[subscript 855]/Vein[subscript 855])/ln(Tissue[subscript 805]/Vein[subscript 805]) with Tissue, Art, and Vein representing total a-scan reflectance at the 805- or 855-nm centered bandwidth. Arterial and venous ODRs were compared by the Wilcoxon signed rank test. Arterial ODRs were significantly greater than venous ODRs (1.007 ± 2.611 and −1.434 ± 4.310, respectively; p = 0.0217) (mean±standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1117/1.2772655
