A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions
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Buchwald_A new biarylphosphine.pdf
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Author(s)
Salvi, Luca
Ali, Siraj Z.
Davis, Nicole Rose
Buchwald, Stephen Leffler
Date Issued
December 2011
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Salvi, Luca, Nicole R. Davis, Siraj Z. Ali, and Stephen L. Buchwald. “A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions.” Organic Letters 14, no. 1 (January 6, 2012): 170-173.
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Author's final manuscript
Abstract
A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C–O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible. A direct correlation between the size of the ligand substituents in the 2′, 4′, and 6′ positions of the nonphosphine containing ring and the reactivity of the derived catalyst system was observed. Specifically, the rate of coupling increased with the size of these substituents.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol202955h
