A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
Name
a-concise-route-to-mk-4482-eidd-2801-from-cytidine-part-2.pdf
Description
Submitted version
Size
73.16 KB
Format
Unknown
Checksum (MD5)
04d16f33187c26f54315f06e26dd0668
Author(s)
Snead, David R.
Gopalsamuthiram, Vijayagopal
Williams, Corshai
Noble, Jeffrey
Jamison, Timothy F.
Gupton, B. Frank
Date Issued
September 2020
Journal
Synlett
Publisher
Georg Thieme Verlag KG
Citation
Gopalsamuthiram, Vijayagopal, Williams, Corshai, Noble, Jeffrey, Jamison, Tim, Gupton, B Frank et al. 2021. "A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2." Synlett, 32 (03). © 2021 Georg Thieme Verlag. All rights reserved.
Version
Original manuscript
Abstract
A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1055/a-1275-2848
