Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network
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Langer_Fabrication of.pdf
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Author(s)
Bellan, Leon M.
Kniazeva, Tatiana
Kim, Ernest S.
Epshteyn, Alla A.
Cropek, Donald M.
Borenstein, Jeffrey T.
Langer, Robert S
Date Issued
March 2012
Journal
Advanced Healthcare Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Bellan, Leon M., Tatiana Kniazeva, Ernest S. Kim, Alla A. Epshteyn, Donald M. Cropek, Robert Langer, and Jeffrey T. Borenstein. “Fabrication of a Hybrid Microfluidic System Incorporating Both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network.” Advanced Healthcare Materials 1, no. 2 (January 20, 2012): 164–167.
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Author's final manuscript
Abstract
A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.
MIT Department
Charles Stark Draper Laboratory
Massachusetts Institute of Technology. Center for Biomedical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1002/adhm.201100052
